Executive summary Despite substantial progress in reducing the global impact of many non-communicable diseases, including heart disease and cancer, morbidity and mortality due to chronic respiratory disease continues to increase. This increase is driven primarily by the growing burden of chronic obstructive pulmonary disease (COPD), and has occurred despite the […]
Pulmonary immunothrombosis critical in #COVID19 #ARDS pathogenesis:*local endotheliopathy due to specific deleterious effects of #SARSCoV2 infection upon pulmonary endothelial cells* thrombocytopathy: multifactorial platelet activation* enhanced vascular permeability, facilitating leucocyte extravasation/exacerbating alveolar infammation & edemanet effect? generation of platelet–fibrin rich thrombi disseminated throughout pulmonary vasculature.Complex multifactorial mechanisms involved, unlikely one-size-fits-all approach will be enough: […]
