Pulmonary immuno‑thrombosis in COVID‑19 ARDS pathogenesis

  Pulmonary immunothrombosis critical in #COVID19 #ARDS pathogenesis:*local endotheliopathy due to specific deleterious effects of #SARSCoV2 infection upon pulmonary endothelial cells* thrombocytopathy: multifactorial platelet activation* enhanced vascular permeability, facilitating leucocyte extravasation/exacerbating alveolar infammation & edemanet effect? generation of platelet–fibrin rich thrombi disseminated throughout pulmonary vasculature.Complex multifactorial mechanisms involved, unlikely one-size-fits-all approach will be enough: […]