A new statistical analysis of an existing meta-analysis reaffirms a finding that hospitalized patients with COVID-19 who are on simple oxygen or noninvasive ventilation can benefit from treatment with the arthritis drug tocilizumab (Actemra) in conjunction with corticosteroids. But the report also casts doubt on the effectiveness of tocilizumab in patients who are on […]
Some authors of a widely reported meta-analysis of ivermectin studies that was flagged for including potentially fraudulent research have just posted a re-analysis on a preprint server — and ivermectin’s seemingly beneficial effects disappeared as trial quality went up. For the re-analysis, Andrew Hill, PhD, of the University of Liverpool in England, and colleagues […]
Abstract Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19). Design Living systematic review and network meta-analysis. Data sources WHO covid-19 database, a comprehensive multilingual source of global covid-19 literature, up to 1 March 2021 and six additional Chinese databases up to 20 February 2021. Studies identified as of 12 […]
Post-hoc analysis of ChAdOx1 nCoV-19 vaccine efficacy against B.1.1.7 variant shows reduced neutralisation activity compared with a non-B.1.1.7 variant in vitro, but supports ongoing use of the vaccine in vaccination programmes given degree of efficacy. Read https://hubs.li/H0KdKSs0 In a linked Comment, Rogier Sanders and Menno de Jong suggest the early […]
