Moderna and Pfizer Vaccines Show Best Immune Response as Boosters

Seven different COVID-19 vaccines increase immunity when used as a booster for people who have had two doses of AstraZeneca/Oxford vaccine, and 6 vaccines provide immunity as boosters after 2 doses of Pfizer/BioNTech, a study has shown. However there were large variations in antibody and cellular immune responses between vaccines.

The COV-BOOST study found that an mRNA booster – such as Moderna or Pfizer – gave the best overall immune response against SARS-CoV-2, irrespective of whether first doses were an mRNA vaccine or AstraZeneca’s chimpanzee adenovirus vectored vaccine.

Results from the randomised phase 2 trial, published in  The Lancet , looked at the safety, immune responses, and side effects of 7 vaccines when used as a third jab.

The trial was designed to inform policy choices for booster vaccination programmes.

Measuring Immune Response and Safety

COV-BOOST looked at the safety, immune responses, and side-effects of 7 vaccines when used as a third, booster jab.

The vaccines included in the trial were:

• AstraZeneca/Oxford

• Pfizer/BioNTech

• Moderna

• Novavax

• Janssen

• Valneva

• Curevac

Of these, only AstraZeneca, Pfizer, Moderna, and Janssen are currently approved for use in the UK.

Study Details

The study, led by the University of Southampton, involved 2878 healthy people aged 30 and older who were recruited at 18 UK sites between June 1 and June 30, 2021.

https://www.medscape.com/viewarticle/964096?src=soc_fb_211203_mscpedt_news_mdscp_study&faf=1

Créditos: Comité científico Covid